http://www.legislation.gov.uk/uksi/2014/1663/schedule/4/part/1The Genetically Modified Organisms (Contained Use) Regulations 2014texttext/xmlenStatute Law DatabaseHEALTH AND SAFETY2025-12-09Expert Participation2025-11-13 SCHEDULE 4 PART 1 1The following matters must be taken into account in carrying out an assessment for the purposes of regulation 6—aany potentially harmful effects, in particular those associated with—ithe recipient organism;iithe inserted genetic material (originating from the donor organism);iiithe vector;ivthe donor organism;vthe resulting genetically modified organism;bthe characteristics of the contained use;cthe severity of the potentially harmful effects;dthe likelihood of the potentially harmful effects being realised.2In paragraph 1, “potentially harmful effects” includes—adisease to humans including allergenic or toxic effects;bacting as a human disease vector or reservoir;cadverse effects to humans arising from change in behaviour or in physical nature;dadverse effects arising from the inability to treat human disease or offer effective prophylaxis.