SCHEDULE 2CRITERIA FOR THE CLASSIFICATION OF ORGANISMS

PART ICriteria as applicable for classification of micro-organisms in Group I

Vectors/Insert2

a

well characterised and free from known harmful sequences;

b

limited in size as much as possible to the genetic sequences required to perform the intended function;

c

should not increase the stability of the construct in the environment (unless that is a requirement of intended function);

d

should be poorly mobilisable;

e

should not transfer any resistance markers to micro-organisms not known to acquire them naturally (if such acquisition could compromise use of drugs to control disease agents).