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2.—(a) well characterised and free from known harmful sequences;
(b)limited in size as much as possible to the genetic sequences required to perform the intended function;
(c)should not increase the stability of the construct in the environment (unless that is a requirement of intended function);
(d)should be poorly mobilisable;
(e)should not transfer any resistance markers to micro-organisms not known to acquire them naturally (if such acquisition could compromise use of drugs to control disease agents).
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