| 5 1 770 | Alpharma (Belgium) BVBA |
Maduramicin ammonium alpha 10 g/kg
(Cygro 10 G)
|
Additive Composition
Maduramicin ammonium alpha: 10 g/kg
Carboxymethylcellulose sodium: 20 g/kg
Calcium sulphate dihydrate: 970 g/kg
Active substance
Maduramicin ammonium alpha C47H83O17N
CAS number: 84878-61-5
(2R, 3S, 4S, 5R, 6S)-6[(1R)-1- [(2S,5R,7S,8R,9S)-2-
[2S,2′R,3′S,5R,5
′R)-3′-[(2,6-dideoxy-3,4-di-
O-methyl-β-L-arabinohexopyra
nosyl)oxy]-octahydro-2-
methyl-5′-[(2S,3S,5R,6S)-
tetrahydro-6-hydroxy-3,5,6-
trimethyl-2H-pyran-
2-yl][2,2′-bifuran]-5-yl]-9-
hydroxy-2,8-dimethy-
1,6dioxaspirol[4.5]dec-7-
yl]ethyl]tetrahydro-
2-hydroxy-4,5-
dimethoxy-3-
methyl-3H-pyran-2-acetic
acid, monoammonium
salt produced by a fermentation process by the strain Actinomadura
yumaensis NRRL 12515: ≥ 90 %.
Related impurities:
Maduramicin ammonium β: ≤ 1 %
Analytical method
For the determination of maduramicin ammonium alpha in the additive, premixtures and feedingstuffs: reversed-phased high performance liquid chromatography (HPLC) using post-column derivatization with vanillin and detection at 520nm- EN 15781:2009.
For the determination of residues of maduramicin ammonium alpha in liver and muscle: reversed-phased high performance liquid chromatography (HPLC) coupled to tandem mass spectrometry.
| Chickens for fattening | — | 5 | 6 |
1.
The additive shall be incorporated in compound feed in form of a premixture.
2.
Maduramicin ammonium alpha shall not be mixed with other coccidiostats.
3.
Indicate in the instructions for use: ‘Dangerous for equines’.
‘This feedingstuff contains an ionophore: simultaneous use with certain medicinal substances (e.g. tiamulin) can be contraindicated’.
4.
For safety: breathing protection, glasses and gloves shall be used during handling.
5.
A post-market monitoring program on the resistance to Eimeria spp. shall be planned and executed by the holder of authorisation.
6.
The use is prohibited at least 3 days before slaughter
| 10 May 2021 |
150 μg of maduramycin ammonium/kg of fresh liver, skin and fat;
100 μg of maduramycin ammonium/kg of fresh kidney;
30 μg of maduramycin ammonium/kg of fresh muscle.
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