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ANNEX
1.
EXPLANATION OF THE SECTIONS USED IN THE DEFINITION AND CLASSIFICATION...
Clinical criteria
Laboratory criteria
Epidemiological criteria and epidemiological link
Case classification
Possible case
Probable case
Confirmed case
Laboratory-confirmed case with clinical criteria
Laboratory-confirmed case with unknown clinical criteria
Laboratory-confirmed case without clinical criteria
2.
CASE DEFINITIONS OF COMMUNICABLE DISEASES
2.1.
ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS) AND HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION...
Clinical Criteria (AIDS)
Laboratory Criteria (HIV)
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.2.
ANTHRAX (Bacillus anthracis)
Clinical Criteria
Cutaneous anthrax
Gastrointestinal anthrax
Inhalational anthrax
Meningeal/meningoencephalitic anthrax
Anthrax septicaemia
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.3.
AVIAN INFLUENZA A/H5 OR A/H5N1 IN HUMANS
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Nationally confirmed case
D.
WHO confirmed case
2.4.
BOTULISM (Clostridium botulinum)
Clinical Criteria
Food-borne and wound botulism
Infant botulism
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.5.
BRUCELLOSIS (Brucella spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.6.
CAMPYLOBACTERIOSIS (Campylobacter spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.7.
CHLAMYDIAL INFECTION (Chlamydia trachomatis), INCLUDING LYMPHOGRANULOMA VENEREUM (LGV)
Clinical Criteria
Chlamydial infection non-LGV
LGV
Laboratory Criteria
Chlamydial infection non-LGV
LGV
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.8.
CHOLERA (Vibrio cholerae)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.9.
CREUTZFELDT-JAKOB DISEASE, VARIANT (vCJD)
Preconditions
Clinical Criteria
Diagnostic Criteria
Diagnostic criteria for case confirmation:
Diagnostic criteria for a probable or a possible case:
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.10.
CRYPTOSPORIDIOSIS (Cryptosporidium spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.11.
DIPHTHERIA (Corynebacterium diphtheriae, Corynebacterium ulcerans and Corynebacterium pseudotuberculosis)
Clinical Criteria
Classic Respiratory Diphtheria:
Mild Respiratory Diphtheria:
Cutaneous Diphtheria:
Diphtheria of other sites:
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.12.
ECHINOCOCCOSIS (Echinococcus spp.)
Clinical Criteria
Diagnostic Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.13.
GIARDIASIS (Giardia lamblia)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.14.
GONORRHOEA (Neisseria gonorrhoeae)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.15.
HAEMOPHILUS INFLUENZAE, INVASIVE DISEASE (Haemophilus influenzae)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.16.
HEPATITIS A (Hepatitis A virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.17.
HEPATITIS B (Hepatitis B virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.18.
HEPATITIS C (Hepatitis C virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.19.
INFLUENZA (Influenza virus)
Clinical Criteria
Influenza-like illness (ILI)
Acute respiratory infection (ARI)
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.20.
INFLUENZA A(H1N1)
Clinical criteria
Laboratory criteria
Epidemiological criteria
Case classification
A.
Case under investigation
B.
Probable case
C.
Confirmed case
2.21.
LEGIONNAIRES’ DISEASE (Legionella spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.22.
LEPTOSPIROSIS (Leptospira spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.23.
LISTERIOSIS (Listeria monocytogenes)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Additional information
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.24.
MALARIA (Plasmodium spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.25.
MEASLES (Measles virus)
Clinical Criteria
Laboratory Criteria
Epidemiological criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.26.
MENINGOCCOCAL DISEASE, INVASIVE (Neisseria meningitidis)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.27.
MUMPS (Mumps virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.28.
PERTUSSIS (Bordetella pertussis)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.29.
PLAGUE (Yersinia pestis)
Clinical Criteria
Bubonic plague:
Septicaemic plague:
Pneumonic plague:
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.30.
PNEUMOCOCCAL INVASIVE DISEASE(S) (Streptococcus pneumoniae)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.31.
POLIOMYELITIS (Polio virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.32.
Q FEVER (Coxiella burnetii)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.33.
RABIES (Lyssa virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.34.
RUBELLA (Rubella virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.35.
RUBELLA, CONGENITAL (Including Congenital Rubella Syndrome)
Clinical Criteria
Congenital rubella infection (CRI)
Congenital rubella syndrome (CRS)
(A)
(B)
Laboratory Criteria
Epidemiological Criteria
Case Classification Congenital Rubella
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.36.
SALMONELLOSIS (Salmonella spp. other than Salmonella typhi and Salmonella paratyphi)...
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.37.
SEVERE ACUTE RESPIRATORY SYNDROME — SARS (SARS-coronavirus, SARS-CoV)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification for the inter-epidemic period
A.
Possible case
B.
Probable case
C.
Nationally confirmed case
D.
Confirmed case
Case Classification during an outbreak
A.
Possible case
B.
Probable case
C.
Nationally confirmed case
D.
Confirmed case
2.38.
SHIGA TOXIN/VEROCYTO-TOXIN PRODUCING ESCHERICHIA COLI INFECTION (STEC/VTEC)
Clinical Criteria
STEC/VTEC diarrhoea
HUS
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case of STEC-associated HUS
B.
Probable case of STEC/VTEC
C.
Confirmed case of STEC/VTEC
2.39.
SHIGELLOSIS (Shigella spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.40.
SMALLPOX (Variola virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.41.
SYPHILIS (Treponema pallidum)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.42.
SYPHILIS, CONGENITAL AND NEONATAL (Treponema pallidum)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.43.
TETANUS (Clostridium tetani)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.44.
TICK-BORNE ENCEPHALITIS (TBE virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.45.
TOXOPLASMOSIS, CONGENITAL (Toxoplasma gondii)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case NA
B.
Probable case NA
C.
Confirmed case
2.46.
TRICHINELLOSIS (Trichinella spp.)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.47.
TUBERCULOSIS (Mycobacterium tuberculosis complex)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria NA
Case Classification
A.
Possible case
B.
Probable case
C.
Confirmed case
2.48.
TULARAEMIA (Francisella tularensis)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.49.
TYPHOID/PARATYPHOID FEVER (Salmonella typhi/paratyphi)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.50.
VIRAL HAEMORRHAGIC FEVERS (VHF)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.51.
WEST NILE FEVER (West Nile virus infection, WNV)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.52.
YELLOW FEVER (Yellow fever virus)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
2.53.
YERSINIOSIS (Yersinia enterocolitica, Yersinia pseudotuberculosis)
Clinical Criteria
Laboratory Criteria
Epidemiological Criteria
Case Classification
A.
Possible case NA
B.
Probable case
C.
Confirmed case
3.
CASE DEFINITIONS OF SPECIAL HEALTH ISSUES
3.1.
GENERAL CASE DEFINITION OF NOSOCOMIAL INFECTION (OR ‘HEALTHCARE-ASSOCIATED INFECTION’)
3.1.1.
BJ: BONE AND JOINT INFECTION
BJ-BONE: Osteomyelitis
BJ-JNT: Joint or bursa
BJ-DISC: Disc space infection
3.1.2.
BSI: BLOODSTREAM INFECTION
BSI: Laboratory-confirmed bloodstream infection
3.1.3.
CNS: CENTRAL NERVOUS SYSTEM INFECTION
CNS-IC: Intracranial infection (brain abscess, subdural or epidural infection, encephalitis)...
CNS-MEN: Meningitis or ventriculitis
CNS-SA: Spinal abscess without meningitis
3.1.4.
CRI: CATHETER-RELATED INFECTION
CRI1-CVC: Local CVC-related infection (no positive blood culture)
CRI1-PVC: Local PVC-related infection (no positive blood culture)
CRI2-CVC: General CVC-related infection (no positive blood culture)
CRI2-PVC: General PVC-related infection (no positive blood culture)
CRI3-CVC: microbiologically confirmed CVC-related bloodstream infection
CRI3-PVC: microbiologically confirmed PVC-related bloodstream infection
3.1.5.
CVS: CARDIOVASCULAR SYSTEM INFECTION
CVS-VASC: Arterial or venous infection
CVS-ENDO: Endocarditis
CVS-CARD: Myocarditis or pericarditis
CVS-MED: Mediastinitis
3.1.6.
EENT: EYE, EAR, NOSE, THROAT, OR MOUTH INFECTION
EENT-CONJ: Conjunctivitis
EENT-EYE: Eye, other than conjunctivitis
EENT-EAR: Ear mastoid
EENT-ORAL: Oral cavity (mouth, tongue, or gums)
EENT-SINU: Sinusitis
EENT-UR: Upper respiratory tract, pharyngitis, laryngitis, epiglottitis
3.1.7.
GI: GASTROINTESTINAL SYSTEM INFECTION
GI-CDI: Clostridium difficile infection
GI-GE: Gastroenteritis (excl. CDI)
GI-GIT: Gastrointestinal tract (oesophagus, stomach, small and large bowel, and...
GI-HEP: Hepatitis
GI-IAB: Intraabdominal, not specified elsewhere including gallbladder, bile ducts, liver...
3.1.8.
LRI: LOWER RESPIRATORY TRACT INFECTION, OTHER THAN PNEUMONIA
LRI-BRON: Bronchitis, tracheobronchitis, bronchiolitis, tracheitis, without evidence of pneumonia
LRI-LUNG: Other infections of the lower respiratory tract
3.1.9.
NEO: SPECIFIC NEONATAL CASE DEFINITIONS
NEO-CSEP: Clinical Sepsis
NEO-LCBI: Laboratory-confirmed BSI
NEO-CNSB: Laboratory-confirmed BSI with coagulase-negative staphylococci (CNS)
NEO-PNEU: Pneumonia
NEO-NEC: Necrotising enterocolitis
3.1.10.
PN: PNEUMONIA
(a)
Bacteriologic diagnostic performed by:
(b)
Alternative microbiology methods (PN 3)
(c)
Others
Intubation-associated pneumonia (IAP)
3.1.11.
REPR: REPRODUCTIVE TRACT INFECTION
REPR-EMET: Endometritis
REPR-EPIS: Episiotomy
REPR-VCUF: Vaginal cuff
REPR-OREP: Other infections of the male or female reproductive tract...
3.1.12.
SSI: SURGICAL SITE INFECTION
Superficial incisional (SSI-S)
Deep incisional (SSI-D)
Organ/Space (SSI-O)
3.1.13.
SST: SKIN AND SOFT TISSUE INFECTION
SST-SKIN: Skin infection
SST-ST: Soft tissue (necrotising fascitis, infectious gangrene, necrotising cellulitis, infectious...
SST-DECU: Decubitus ulcer, including both superficial and deep infections
SST-BURN: Burn
SST-BRST: Breast abscess or mastitis
3.1.14.
SYS: SYSTEMIC INFECTION
SYS-DI: Disseminated infection
SYS-CSEP: Clinical sepsis in adults and children
3.1.15.
UTI: URINARY TRACT INFECTION
UTI-A: microbiologically confirmed symptomatic UTI
UTI-B: not microbiologically confirmed symptomatic UTI
3.2.
GENERIC CASE DEFINITION OF ANTIMICROBIAL RESISTANCE
Definition
Clinically Susceptible (S)
Clinically Intermediate (I)
Clinically Resistant (R)
Clinical breakpoints are presented as S≤x mg/L; I>x, ≤y mg/L;...
Commission Decision
of 19 March 2002
laying down case definitions for reporting communicable diseases to the Community network under Decision No 2119/98/EC of the European Parliament and of the Council
(notified under document number C(2002) 1043)
(2002/253/EC) (repealed)
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Repealed by Commission Implementing Decision (EU) 2018/945 of 22 June 2018 on the communicable diseases and related special health issues to be covered by epidemiological surveillance as well as relevant case definitions (Text with EEA relevance).